Male-driven evolution
Li, W-H., Yi, S. and K. D. Makova.
Current Opinions in Genetics and Development, 12:650-656, 2002.

• Abstract: The strength of male-driven evolution - that is, the magnitude of the sex ratio of mutation rate - has been a controversial issue, particularly in primates. While earlier studies estimated the male-to-female ratio (alpha) of mutation to be about 4-6 in higher primates, two recent studies claimed that alpha is only about 2 in humans. However, a recent comparison of mutation rates between a noncoding fragment on Y and a homologous region on chromosome 3 reinstated strong male-driven evolution in hominoids. Several studies investigated variation in mutation rates among genomic regions that may not be related to sex differences and found strong evidence for such variation. The causes for regional variation in mutation rate are not clear but GC content and recombination are two possible causes.